Post-exposure prophylaxis (PEP) with doxycycline has been shown to reduce rates of bacteria sexually transmitted infections in clinical trials, and while for...
Our study on Neisseria gonorrhoeae escape from sequence based ciprofloxacin diagnostics, led by Dr. Dan Rubin, has now been published at Lancet Microbe!
Point-of-care diagnostics for antimicrobial susceptibility of Neisseria gonorrhoeae being developed with the goal of reintroducing previously used therapies....
Sky Martin’s in-depth review of machine learning models for antimicrobial susceptibility testing is now available at the Annals of the New York Academy of Sc...
After many years of work from the Pepperell lab, Tracy Smith and Madison Youngblom’s experimental evolution of M. tuberculosis biofilms has now been publishe...
Chris Hadjineophytou’s manuscript on protein glycosylation by PglO across the Neisseria genus has been published in mBio!
I wrote a commentary on a recent publication in mBio where Ayala and colleagues identified a single nucleotide variant in gdhR in Neisseria gonorrhoeae and e...
Point-of-care diagnostics for antimicrobial susceptibility of Neisseria gonorrhoeae are a promising tool to reintroduce previous gonorrhea treatment regimens...
A new publication from Dr. Crista Wadsworth’s lab and led by Thomas Murphy describing genome sequences of three penicillin resistant Neisseria gonorrhoeae is...
While Neisseria gonorrhoeae generally infects mucosal surfaces in the cervix, pharynx, rectum, and urethra, it can occasionally cause disseminated infection....
Dr. Carolin Vegvari’s manuscript modeling the impact of rapid point-of-care tests to minimize the emergence of resistance to gepotidicin in Neisseria gonorrh...
Check out this preprint on a project led by Dr. Koji Yahara describing the emergence of cephalosporin resistant lineages of Neisseria gonorrhoeae encoding mo...
Check out this manuscript led by Kevin Ma using conditional GWAS to discover mutations in rplD associated with azithromycin resistance in Neisseria gonorrhoe...
Gonorrhea is the second most commonly reported sexually transmitted infection in the United States, and rates have been rapidly climbing over the last decade...
Check out this preprint on a project led by Dr. Leonor Sanchez-Buso describing the Neisseria gonorrhoeae scheme for Pathogenwatch, which provides typing and ...
Our project, led by Lindsey Bohr, characterizing recombination in Gardnerella is now published in Fronteirs in Cellular and Infection Microbiology!
Since 2009, rates of gonorrhea have been increasing in the United States. Rates vary across sexual behavior groups and races/ethnicities. However, we don’t k...
Check out this project led by Dr. Samantha Palace discovering a novel mechanism of cephalosporin resistance in Neisseria gonorrhoeae mediated by mutations in...
Check out this manuscript led by Dr. Allison Hicks evaluating sampling strategies for phenotypic testing to identify novel genetic variants associated with a...
Project led by Dr. Alexander Doroshenko describing tuberculosis outbreaks in First Nations communities in Alberta, Canada.
Review article co-authored with Yonatan Grad on genomics of Neisseria gonorrhoeae.
While most bacteria undergo lateral gene transfer, including other mycobacteria, M. tuberculosis evolves clonally. Most methods to detect positive selection ...
Staphylococcus saprophyticus is one of the leading causes of urinary tract infections. However, prior to our ancient genome study described above, the genome...
Distributive conjugal transfer (DCT) in M. smegmatis is regulated by ESX-1 and ESX-4, which are loci encoding type VII secretion systems (T7SS). Mycobacteria...
Reconstruction of pathogen genomes from ancient DNA has provided important insights into the evolution of major pathogens including Mycobacterium tuberculosi...
A method devoloped by Dr. Utkarsh Dang to estimate rates of gene gain and loss in the presence of missing data has been published in Genetics!
Project led by Dr. Mary O’Neill investigating diversity and targets of selection within and between hosts in Mycobacterium tuberculosis.
Distributive conjugal transfer (DCT) is a mechanism of lateral gene transfer (LGT) first discovered in the nonpathogenic model organism Mycobacterium smegmat...
Dr. Louise Moncla’s project describing influenza infection and transmission in a marmoset model using deep sequencing.